Developing new treatments for seizures caused by nerve agents in children and the elderly
Novel pediatric anticonvulsants for nerve agents
['FUNDING_U01'] · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · NIH-10916468
This study is testing a new treatment called ganaxolone to help prevent seizures and protect the brains of children and older adults who are at risk from nerve agents and certain poisons, aiming to find a better option than what’s currently available.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR (nih funded) |
| Locations | 1 site (COLLEGE STATION, UNITED STATES) |
| Trial ID | NIH-10916468 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a new neurosteroid therapy to help prevent seizures and reduce the harmful effects of nerve agents and organophosphate poisoning in children and elderly individuals. The study aims to optimize a specific anticonvulsant that can effectively control seizures and protect the brain from damage. By testing the synthetic neurosteroid ganaxolone, the researchers hope to find a more effective treatment than current options, which often do not provide adequate protection against prolonged seizures. The approach involves evaluating the safety and efficacy of this new therapy in vulnerable populations who are at higher risk of neurotoxicity.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and elderly individuals who have been exposed to nerve agents or organophosphate compounds.
Not a fit: Patients who do not fall within the pediatric or elderly age groups or who have not been exposed to nerve agents may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective treatment for seizures caused by nerve agents, significantly improving outcomes for affected patients.
How similar studies have performed: Previous studies have shown that neurosteroids can effectively control seizures and brain injury in adult models, suggesting a promising avenue for this research.
Where this research is happening
COLLEGE STATION, UNITED STATES
- TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR — COLLEGE STATION, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REDDY, DOODIPALA SAMBA — TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
- Study coordinator: REDDY, DOODIPALA SAMBA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury