Developing new treatments for neurological disorders using advanced technology
Official title: BRITE-Eye: An integrated discovery engine for CNS therapeutic targets driven by high throughput genetic screens, functional readouts in human neurons, and machine learning
Funded at Quiver Bioscience INC. · NIH-10931401 · Data updated 2026-11-12
This study is exploring new ways to find better treatments for neurological disorders, like epilepsy, by using cutting-edge technology to look at human brain cells and see how they react, which could lead to more effective therapies for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Quiver Bioscience INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,278,054 |
| NIH project number | 5R44MH135521-02 |
| Project ID | NIH-10931401 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neurological disorders such as epilepsy or other central nervous system conditions.
✕Less likely to help
Patients with non-neurological conditions or those not affected by CNS disorders may not receive any benefit from this research.
What this research studies
This research focuses on improving the discovery of new treatments for neurological disorders by utilizing advanced technologies. It combines high throughput screening of human neurons, CRISPR gene editing to disrupt specific genes, and machine learning to analyze complex physiological data. By assessing individual neurons and their responses, the research aims to identify potential therapeutic targets that could lead to better treatments for conditions like epilepsy and other CNS disorders. Patients may benefit from more effective therapies developed through this innovative approach.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective treatments for various neurological disorders.
How similar studies have gone: Other research has shown promise in using CRISPR and machine learning for drug discovery, indicating that this approach could yield significant advancements.
Where this research is happening
-
Quiver Bioscience INC.
Cambridge, United States Active
Researchers
- Principal investigator: Williams, Luis Alberto — Quiver Bioscience INC.
- Study coordinator: Williams, Luis Alberto
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.