Developing new treatments for neuroblastoma by targeting a specific protein
Targeting the chromatin binding domains of BPTF for neuroblastoma epigenetic therapy
This study is working on developing special tools to block a protein called BPTF that helps neuroblastoma grow, with the hope of finding new treatments for kids battling this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11050606 on NIH RePORTER |
What this research studies
This research aims to create specialized chemical probes that can target and disrupt the function of a protein called BPTF, which plays a crucial role in the development of neuroblastoma, a type of cancer primarily affecting children. By understanding how BPTF interacts with chromatin, the research seeks to identify new therapeutic strategies that could inhibit cancer growth. The approach involves detailed biochemical assays and genetic studies to explore the effects of reducing BPTF levels on cancer cell viability. If successful, this could lead to innovative treatments for patients suffering from neuroblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neuroblastoma, particularly those with high BPTF expression levels.
Not a fit: Patients with neuroblastoma who have low BPTF expression or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for children with neuroblastoma, potentially improving survival rates and reducing disease recurrence.
How similar studies have performed: Other research has shown promise in targeting chromatin remodeling complexes for cancer treatment, indicating that this approach could be a viable strategy.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Fischer, Marcus — St. Jude Children's Research Hospital
- Study coordinator: Fischer, Marcus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.