Developing new treatments for neuroblastoma by targeting a specific protein
Official title: Targeting the chromatin binding domains of BPTF for neuroblastoma epigenetic therapy
Funded at St. Jude Children's Research Hospital · NIH-11050606 · Data updated 2026-11-12
This study is working on developing special tools to block a protein called BPTF that helps neuroblastoma grow, with the hope of finding new treatments for kids battling this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $738,024 |
| NIH project number | 1R01CA290805-01A1 |
| Project ID | NIH-11050606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with neuroblastoma, particularly those with high BPTF expression levels.
✕Less likely to help
Patients with neuroblastoma who have low BPTF expression or those with other types of cancer may not benefit from this research.
What this research studies
This research aims to create specialized chemical probes that can target and disrupt the function of a protein called BPTF, which plays a crucial role in the development of neuroblastoma, a type of cancer primarily affecting children. By understanding how BPTF interacts with chromatin, the research seeks to identify new therapeutic strategies that could inhibit cancer growth. The approach involves detailed biochemical assays and genetic studies to explore the effects of reducing BPTF levels on cancer cell viability. If successful, this could lead to innovative treatments for patients suffering from neuroblastoma.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for children with neuroblastoma, potentially improving survival rates and reducing disease recurrence.
How similar studies have gone: Other research has shown promise in targeting chromatin remodeling complexes for cancer treatment, indicating that this approach could be a viable strategy.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Fischer, Marcus — St. Jude Children's Research Hospital
- Study coordinator: Fischer, Marcus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.