Developing new treatments for Lyme disease by targeting bacterial flagella.
Toward novel therapies against Lyme disease through the inhibition of lysinoalaine cross-linking in the bacterial flagella.
This study is looking at how certain bacteria, like those that cause Lyme disease, move and invade our bodies, and it aims to find new ways to stop them by targeting a special part of their movement system, which could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10894290 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain bacteria, including those that cause Lyme disease, use their flagella to move and invade human tissues. The team aims to investigate a specific amino acid cross-link that strengthens the flagella, which may contribute to the bacteria's ability to cause disease. By exploring the structure and function of this cross-link, the researchers hope to develop new drugs that can inhibit this process, potentially leading to more effective treatments for Lyme disease. Patients may benefit from these novel therapies if they are successful in reducing the severity or duration of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Lyme disease or those experiencing symptoms related to this condition.
Not a fit: Patients who do not have Lyme disease or related spirochetal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively treat Lyme disease and reduce its long-term health impacts.
How similar studies have performed: While the approach of targeting bacterial flagella is promising, it is relatively novel and has not been extensively tested in the context of Lyme disease.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Crane, Brian R — Cornell University
- Study coordinator: Crane, Brian R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.