Developing new treatments for infections caused by Pseudomonas aeruginosa
Targeting lipopolysaccharide transport machinery in Pseudomonas aeruginosa
This study is looking for new ways to help fight infections caused by a tough germ called Pseudomonas aeruginosa, which is hard to treat because it can block antibiotics; researchers are trying to find tiny molecules that can break down this barrier and make it easier for medicines to work.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10766260 on NIH RePORTER |
What this research studies
This research focuses on Pseudomonas aeruginosa, a bacterium that poses significant health risks due to its resistance to many antibiotics. The project aims to understand how this bacterium transports lipopolysaccharides, which form a barrier that prevents antibiotics from entering the cell. By using advanced genomic and chemical techniques, the researchers are identifying small molecules that can disrupt this transport mechanism, potentially leading to new treatments. The study includes optimizing these compounds and understanding their effects on the bacterium's biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by Pseudomonas aeruginosa, particularly those with limited treatment options.
Not a fit: Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that are effective against resistant strains of Pseudomonas aeruginosa.
How similar studies have performed: Other research has shown promise in targeting bacterial transport mechanisms, suggesting that this approach could be effective.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Romano, Keith Patrick — Brigham and Women's Hospital
- Study coordinator: Romano, Keith Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.