Developing new treatments for H. pylori infections
Official title: Targeting NuoD for the treatment of H. pylori
Funded at St. Jude Children's Research Hospital · NIH-11076652 · Data updated 2026-11-12
This study is looking for new and better treatments for Helicobacter pylori infections, which can cause stomach problems like ulcers and cancer, by focusing on a specific part of the bacteria that most other germs don’t use, so we can create antibiotics that work well without upsetting your gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $844,980 |
| NIH project number | 5R01AI170765-03 |
| Project ID | NIH-11076652 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic H. pylori infections, particularly those who have not responded well to standard antibiotic treatments.
✕Less likely to help
Patients who do not have H. pylori infections or those who are not experiencing complications related to this infection may not benefit from this research.
What this research studies
This research focuses on creating more effective and selective therapies for Helicobacter pylori infections, which can lead to serious conditions like peptic ulcers and gastric cancer. The study aims to target a specific part of the bacteria's respiration system, known as NuoD, which is crucial for H. pylori but not for most other bacteria. By using advanced virtual screening methods, researchers are identifying potential new drugs that can effectively combat this drug-resistant pathogen while minimizing harm to the gut microbiome. The goal is to develop antibiotics that are both effective and have fewer side effects compared to current treatments.
Why it matters
Potential benefit: If successful, this research could lead to new antibiotics that effectively treat H. pylori infections with fewer side effects.
How similar studies have gone: Other research has shown promise in targeting specific bacterial pathways, indicating that this approach could be successful.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Lee, Richard E. — St. Jude Children's Research Hospital
- Study coordinator: Lee, Richard E.
Related research
Other NIH-funded projects on the same topics.
-
Investigating frailty and aging in childhood cancer survivors
This study is looking at childhood cancer survivors to see how they might face health challenges similar to older adults as they grow up, and it aims to find ways to help them stay strong and healthy by exploring treatments that could improve their well-being.
-
Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
-
Accessible, label-free optical imaging to reveal disease signals
A brain-friendly, patient-centered imaging approach aims to uncover hidden disease signals in cells and tissues without labels or dyes.
-
Targeting the SCP4 pathway in acute myeloid leukemia (AML)
Aims to uncover how the SCP4 signaling pathway drives AML and how it could be blocked to help patients.
-
Blocking cancer-causing cMYC tricks after pregnancy changes in the breast
Researchers are testing how pregnancy and aging reshape the breast before cancer risk, using patient-reinformed models to see if it changes how dangerous cMYC signals behave.
-
Targeting aberrant enhancer landscapes in pancreatic cancer
A patient-facing look at a project that aims to understand how pancreatic cancer changes its cell identity and what that means for treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.