Developing new treatments for H. pylori infections
Targeting NuoD for the treatment of H. pylori
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11076652
This study is looking for new and better treatments for Helicobacter pylori infections, which can cause stomach problems like ulcers and cancer, by focusing on a specific part of the bacteria that most other germs don’t use, so we can create antibiotics that work well without upsetting your gut health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11076652 on ClinicalTrials.gov |
What this research studies
This research focuses on creating more effective and selective therapies for Helicobacter pylori infections, which can lead to serious conditions like peptic ulcers and gastric cancer. The study aims to target a specific part of the bacteria's respiration system, known as NuoD, which is crucial for H. pylori but not for most other bacteria. By using advanced virtual screening methods, researchers are identifying potential new drugs that can effectively combat this drug-resistant pathogen while minimizing harm to the gut microbiome. The goal is to develop antibiotics that are both effective and have fewer side effects compared to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic H. pylori infections, particularly those who have not responded well to standard antibiotic treatments.
Not a fit: Patients who do not have H. pylori infections or those who are not experiencing complications related to this infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antibiotics that effectively treat H. pylori infections with fewer side effects.
How similar studies have performed: Other research has shown promise in targeting specific bacterial pathways, indicating that this approach could be successful.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, RICHARD E. — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: LEE, RICHARD E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.