Developing new treatments for glioblastoma using DNA damage response inhibitors.
Administrative Core
This study is exploring new ways to treat glioblastoma, a type of brain tumor, by combining new medicines that help fix DNA damage with current treatments to make them work better, using models from patients to test these combinations before moving on to early clinical trials.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10923863 on NIH RePORTER |
What this research studies
This research focuses on creating innovative therapeutic strategies for glioblastoma, a type of brain tumor. The approach involves combining new DNA damage response inhibitors with existing treatments to enhance their effectiveness. The research will utilize patient-derived models to test these combinations and will eventually lead to pilot clinical trials. The Administrative Core will coordinate the various aspects of the research, ensuring collaboration and integration of findings across different projects and teams.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who may benefit from novel therapeutic strategies.
Not a fit: Patients with other types of brain tumors or those not diagnosed with glioblastoma may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with glioblastoma, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in using DNA damage response inhibitors in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sarkaria, Jann N. — Mayo Clinic Rochester
- Study coordinator: Sarkaria, Jann N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.