Developing new treatments for glioblastoma by targeting ATG4B
Targeting ATG4B to Treat Glioblastoma
This study is looking for new ways to treat glioblastoma, a tough brain tumor, by developing special medicines that target a protein called ATG4B, which could help improve survival and quality of life for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10605245 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive brain tumor with a poor prognosis, and aims to develop new treatments by targeting a specific protease called ATG4B. The approach involves creating inhibitors for ATG4B through a collaborative process that includes optimizing existing compounds, assessing their ability to cross the blood-brain barrier, and testing their effectiveness in combination with standard therapies. Patients may benefit from innovative treatment options that could improve survival rates and quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who are seeking new treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve outcomes for patients with glioblastoma.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in cancer treatment, suggesting potential for success in this novel approach.
Where this research is happening
Chicago, UNITED STATES
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Scheidt, Karl a — Northwestern University
- Study coordinator: Scheidt, Karl a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.