Developing new treatments for fatty liver disease
Therapeutic Mitochondrial Uncouplers
This study is looking at new tiny molecules that could help treat non-alcoholic steatohepatitis (NASH), a liver condition that affects many people, by helping the liver burn fat better and reducing stress on liver cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10834097 on NIH RePORTER |
What this research studies
This research focuses on creating small molecule mitochondrial uncouplers to treat non-alcoholic steatohepatitis (NASH), a serious liver condition affecting millions. The approach involves targeting fat accumulation and oxidative stress in the liver, which are key factors in NASH progression. By using mitochondrial uncouplers, the research aims to enhance fat oxidation and reduce harmful byproducts in liver cells. The project includes preclinical testing in mouse models to evaluate the effectiveness and safety of these new compounds.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis (NASH) or those at risk of developing this liver disease.
Not a fit: Patients with other forms of liver disease unrelated to NASH may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the first FDA-approved treatment for NASH, significantly improving outcomes for patients with this condition.
How similar studies have performed: Previous research has shown promise in using mitochondrial uncouplers for metabolic conditions, indicating potential success for this novel approach in treating NASH.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Santos, Webster L — Virginia Polytechnic Inst and St Univ
- Study coordinator: Santos, Webster L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.