Developing new treatments for drug-resistant malaria
Official title: The development of novel 4-aminoquinolines as therapeutics against multi-drug resistant Plasmodium falciparum
Funded at Oregon Health & Science University · NIH-11088695 · Data updated 2026-11-12
This study is working on new medicines to help fight tough strains of malaria, and if successful, these treatments could help patients who are struggling with the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $51,974 |
| NIH project number | 5F31AI174772-02 |
| Project ID | NIH-11088695 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with malaria, especially those infected with drug-resistant strains.
✕Less likely to help
Patients who do not have malaria or those with non-drug-resistant strains may not benefit from this research.
What this research studies
This research focuses on creating novel 4-aminoquinoline compounds to combat multi-drug resistant strains of the malaria parasite, Plasmodium falciparum. The approach involves screening and modifying existing compounds to enhance their effectiveness and stability against the parasite. By conducting in vitro assays and using murine models, the research aims to identify and optimize new therapeutic agents that can effectively clear malaria infections. Patients with malaria could potentially benefit from these new treatments if they prove successful.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for malaria, particularly in areas where current therapies are failing due to drug resistance.
How similar studies have gone: Previous research has shown promise in developing similar compounds for malaria treatment, indicating a potential for success in this area.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Handford, Mason James — Oregon Health & Science University
- Study coordinator: Handford, Mason James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.