Developing new treatments for burn wound infections caused by antibiotic-resistant bacteria.
Official title: Proof of concept experiments for T3SS inhibitors against burn wound infections
Funded at Microbiotix, INC · NIH-11074661 · Data updated 2026-11-12
This study is looking at a new treatment to help fight infections from a tough bacteria called Pseudomonas aeruginosa that can affect burn wounds, and if successful, it could offer better care for patients dealing with these kinds of infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Microbiotix, INC NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | April 12, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $300,000 |
| NIH project number | 5R41AI183900-02 |
| Project ID | NIH-11074661 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with burn wounds who are at risk of infection from Pseudomonas aeruginosa.
✕Less likely to help
Patients with burn wounds not infected by Pseudomonas aeruginosa or those with other types of infections may not benefit from this research.
What this research studies
This research focuses on creating a new therapy to combat burn wound infections caused by the bacteria Pseudomonas aeruginosa, which is known for its resistance to many antibiotics. The approach involves testing small molecules that inhibit a specific system used by the bacteria to infect and spread within the body. By targeting the type 3 secretion system (T3SS), the research aims to reduce the bacteria's ability to cause harm. Patients with burn wounds may benefit from this innovative treatment if it proves effective.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from burn wound infections, particularly those caused by antibiotic-resistant bacteria.
How similar studies have gone: Previous research has shown promise in targeting the T3SS in similar bacterial infections, indicating potential for success in this novel approach.
Where this research is happening
-
Microbiotix, INC
Worcester, United States Active
Researchers
- Principal investigator: Opperman, Timothy J. — Microbiotix, INC
- Study coordinator: Opperman, Timothy J.
Related research
Other NIH-funded projects on the same topics.
-
Diabetic Foot Ulcer Healing Network at the University of Arizona
A NIH-supported project at the University of Arizona aims to improve healing of diabetic foot ulcers by studying biomarkers and running high-quality clinical trials.
-
Understanding how skin layers coordinate healing after injury
Researchers are studying how different layers of adult skin coordinate rapid healing after injury to prevent infection and chronic wounds.
-
Immunomodulatory therapy to speed up healing after oral cavity injuries in kids
A new approach using a drug called FTY720 aims to improve healing and reduce pain after oral injuries or palate surgery in children.
-
How diabetic wounds let Group B Streptococcus cause infections
Researchers are learning how high blood sugar, immune changes, and other bacteria in diabetic wounds help Group B Streptococcus grow and cause worse infections in people with diabetes.
-
Understanding how skin cells exchange harmful chemicals to cause injury and wound repair
A research project aims to uncover how certain chemical agents damage human skin and what happens in the early stages of blistering and inflammation.
-
Intestinal mucosal wound healing in humans
A patient-friendly look at how the lining of the gut repairs itself after injury and why this matters for conditions like inflammatory bowel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.