Developing new treatments for advanced colorectal cancer using miRNA.
Development of novel miRNA based novel therapeutics for metastatic colorectal cancer
This study is looking at how a tiny molecule called miR-15a affects colorectal cancer and hopes to develop a new treatment that works like it, especially for Veterans with advanced cancer who haven't had success with regular chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northport VA Medical Center NIH-funded |
| Lab location | 1 site (Northport, United States) |
| Project ID | NIH-10881635 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific microRNA, miR-15a, influences colorectal cancer and aims to create a new treatment that mimics this microRNA. The approach involves investigating the role of miR-15a in overcoming resistance to standard chemotherapy, particularly in patients with advanced metastatic colorectal cancer. By targeting the underlying mechanisms of chemoresistance, the research seeks to improve treatment outcomes for patients who have not responded well to existing therapies. The study is particularly relevant for Veterans, who have a high incidence of colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with advanced metastatic colorectal cancer, particularly those who are Veterans.
Not a fit: Patients with early-stage colorectal cancer or those who do not have a diagnosis of colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with advanced colorectal cancer, potentially improving survival rates and quality of life.
How similar studies have performed: While the specific approach of using miR-15a mimics is novel, there is ongoing research into the role of microRNAs in cancer treatment, indicating potential for success.
Where this research is happening
Northport, United States
- Northport VA Medical Center — Northport, United States (Active)
Researchers
- Principal investigator: Ju, Jingfang — Northport VA Medical Center
- Study coordinator: Ju, Jingfang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.