Developing new treatments for advanced colorectal cancer using miRNA.
Official title: Development of novel miRNA based novel therapeutics for metastatic colorectal cancer
Funded at Northport VA Medical Center · NIH-10881635 · Data updated 2026-11-12
This study is looking at how a tiny molecule called miR-15a affects colorectal cancer and hopes to develop a new treatment that works like it, especially for Veterans with advanced cancer who haven't had success with regular chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northport VA Medical Center NIH-funded |
| Lab location | 1 site (Northport, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| NIH project number | 5I01BX005260-03 |
| Project ID | NIH-10881635 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with advanced metastatic colorectal cancer, particularly those who are Veterans.
✕Less likely to help
Patients with early-stage colorectal cancer or those who do not have a diagnosis of colorectal cancer may not benefit from this research.
What this research studies
This research focuses on understanding how a specific microRNA, miR-15a, influences colorectal cancer and aims to create a new treatment that mimics this microRNA. The approach involves investigating the role of miR-15a in overcoming resistance to standard chemotherapy, particularly in patients with advanced metastatic colorectal cancer. By targeting the underlying mechanisms of chemoresistance, the research seeks to improve treatment outcomes for patients who have not responded well to existing therapies. The study is particularly relevant for Veterans, who have a high incidence of colorectal cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with advanced colorectal cancer, potentially improving survival rates and quality of life.
How similar studies have gone: While the specific approach of using miR-15a mimics is novel, there is ongoing research into the role of microRNAs in cancer treatment, indicating potential for success.
Where this research is happening
-
Northport VA Medical Center
Northport, United States Active
Researchers
- Principal investigator: Ju, Jingfang — Northport VA Medical Center
- Study coordinator: Ju, Jingfang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.