Developing new treatments for a deadly brain infection caused by Balamuthia mandrillaris
Novel Structure-Based Therapeutic Discovery for Balamuthia mandrillaris
This study is looking for new treatments to help people with serious brain infections caused by a germ called Balamuthia mandrillaris, and the researchers are using their knowledge of biology and chemistry to find better medicines for those affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11035617 on NIH RePORTER |
What this research studies
This research aims to discover effective therapies for infections caused by Balamuthia mandrillaris, which can lead to a severe brain infection known as granulomatous amoebic encephalitis (GAE). The research team will utilize a combination of expertise in amoeba biology, medicinal chemistry, and molecular modeling to identify and optimize compounds that can effectively target this pathogen. By screening existing compound libraries and using advanced molecular docking techniques, they hope to find new drug candidates that can improve treatment outcomes for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with granulomatous amoebic encephalitis caused by Balamuthia mandrillaris.
Not a fit: Patients with infections caused by other pathogens or those not infected with Balamuthia mandrillaris may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for a currently untreatable and highly fatal brain infection.
How similar studies have performed: Previous research has shown promise in targeting similar pathogens with novel therapeutic approaches, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Ferrins, Lori — Northeastern University
- Study coordinator: Ferrins, Lori
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.