Developing new tools to identify DNA changes linked to cancer.
Novel Chemical Probes for Sequencing Multiple DNA Modifications at Single-Nucleotide Resolution
This study is working on new tools to spot changes in DNA that can happen due to various reasons, helping us learn more about how these changes might influence cancer and gene behavior, which could eventually lead to better ways to diagnose and treat patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-10675459 on NIH RePORTER |
What this research studies
This research focuses on creating innovative chemical probes that can detect various modifications in human DNA, which can be caused by both internal and external factors. By improving the methods used to sequence these DNA modifications, the research aims to better understand their roles in gene regulation and cancer development. The approach involves using advanced sequencing technology to map over ten different DNA modifications at a single-nucleotide level, which could lead to significant insights into how these changes affect health. Patients may benefit from this research as it could enhance our understanding of cancer mechanisms and potentially lead to new diagnostic or therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cancer or those at high risk for developing malignancies due to genetic or environmental factors.
Not a fit: Patients with no known genetic predisposition to cancer or those without any current malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cancers linked to DNA modifications.
How similar studies have performed: Previous research has shown promise in using similar chemical probing techniques to study DNA modifications, indicating a potential for success in this novel approach.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Zhao, Linlin — University of California Riverside
- Study coordinator: Zhao, Linlin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.