Developing new therapies for neurological diseases using patient brain tissue models
A consortium effort to translate therapies for neurological diseases via an ex vivo organotypic platform
This study is looking to improve treatments for brain disorders like Alzheimer's by using real brain tissue from patients to create lab models that help researchers test new therapies in a way that closely resembles how the brain works.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10883757 on NIH RePORTER |
What this research studies
This research focuses on creating advanced models of brain disorders using organotypic brain slice cultures, which incorporate patient tissue to allow for functional testing of potential therapies. By leveraging high-throughput techniques and a multi-disciplinary team from several institutions, the project aims to identify and develop new therapeutic agents for conditions like Alzheimer's disease. Patients' brain tissue will be used to better understand disease mechanisms and test new treatments in a controlled environment that mimics the live brain. This innovative approach seeks to bridge the gap between laboratory research and clinical application.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or other neurological disorders who may provide brain tissue for study.
Not a fit: Patients with neurological disorders not related to Alzheimer's disease or those who are not eligible to provide brain tissue may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from neurological diseases, particularly Alzheimer's disease.
How similar studies have performed: Previous research using similar organotypic models has shown promise in discovering new therapeutic approaches for neurological diseases.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Hingtgen, Shawn — Univ of North Carolina Chapel Hill
- Study coordinator: Hingtgen, Shawn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.