Developing new statistical methods to understand the evolution of infectious diseases.
Statistical innovation to integrate sequences and phenotypes for scalable phylodynamic inference
This study is looking at how quickly diseases like Ebola and HIV change and spread, using advanced methods to analyze their genetic information, so we can better understand these illnesses and help keep people safe during outbreaks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10798209 on NIH RePORTER |
What this research studies
This research focuses on creating advanced statistical methods to analyze how rapidly evolving pathogens, like Ebola and HIV, emerge and spread. By integrating genetic sequences and phenotypic data, the team aims to provide insights into disease evolution and inform public health policies. The approach involves using Bayesian techniques and high-throughput data analysis to study thousands of pathogen genomes and their characteristics from outbreaks. This multidisciplinary effort combines expertise in statistics, data science, and infectious diseases to tackle large-scale epidemics effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals affected by or at risk for infectious diseases like Ebola, HIV, and other rapidly evolving pathogens.
Not a fit: Patients with non-infectious diseases or those not affected by the targeted pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of infectious disease outbreaks, ultimately improving public health responses.
How similar studies have performed: While the integration of phenotype and sequence data at this scale is novel, similar approaches in other contexts have shown promise in understanding disease dynamics.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Suchard, Marc a. — University of California Los Angeles
- Study coordinator: Suchard, Marc a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.