Developing new statistical methods to analyze genetic data from diverse populations
Statistical Methods for Integrative Analysis of Large-Scale Multi-Ethnic Whole Genome Sequencing Studies and Biobanks of Common Diseases
['FUNDING_R01'] · HARVARD SCHOOL OF PUBLIC HEALTH · NIH-11078226
This study is looking at how our genes can affect heart and lung diseases by using a lot of data from different ethnic backgrounds, so we can better understand these conditions for everyone, not just those of European descent.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD SCHOOL OF PUBLIC HEALTH (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11078226 on ClinicalTrials.gov |
What this research studies
This research focuses on creating advanced statistical methods to analyze large-scale Whole Genome Sequencing (WGS) data and biobanks related to common diseases, particularly heart and lung diseases. It aims to address the limitations of existing studies that primarily involve individuals of European ancestry by incorporating data from multi-ethnic populations. By leveraging various omics data and enhancing the analysis of rare genetic variants, the research seeks to uncover genetic factors that contribute to complex diseases across diverse groups. This integrative approach will help improve our understanding of how genetic variations affect health outcomes in different populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from various ethnic backgrounds who are affected by common diseases such as heart and lung conditions.
Not a fit: Patients who do not have common diseases or those who are not from multi-ethnic backgrounds may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate identification of genetic risk factors for diseases, ultimately improving prevention and treatment strategies for diverse populations.
How similar studies have performed: Previous research has shown success in using integrative analysis methods for genetic studies, but this approach specifically targeting multi-ethnic populations is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD SCHOOL OF PUBLIC HEALTH — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIN, XIHONG — HARVARD SCHOOL OF PUBLIC HEALTH
- Study coordinator: LIN, XIHONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders