Developing new sensors to monitor brain activity using MRI without metals
Metal-free, genetically encoded reporters for calcium recording with MRI
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA SANTA BARBARA · NIH-11045067
This study is working on a new way to see how brain cells communicate by using special sensors that can track calcium signals, which could help scientists understand how our experiences shape our behavior, all without using metal-based tools.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA BARBARA (nih funded) |
| Locations | 1 site (SANTA BARBARA, UNITED STATES) |
| Trial ID | NIH-11045067 on ClinicalTrials.gov |
What this research studies
This research focuses on creating innovative genetic sensors that can visualize calcium signals in the brain using MRI technology. By utilizing aquaporins, which are water channels, the researchers aim to develop a method that allows for brain-wide monitoring of neuronal activity without the need for metal-based contrast agents. This approach will enable scientists to study how neurons encode experiences and modify behaviors in living animals, providing insights into brain function and health. The project involves constructing a synthetic multi-gene cluster to enhance the sensitivity and effectiveness of these sensors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those interested in understanding brain function and activity.
Not a fit: Patients with conditions unrelated to neuronal activity or those who are not eligible for MRI procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advanced methods for monitoring brain activity, improving our understanding of neurological conditions and potentially guiding new treatments.
How similar studies have performed: Previous research has shown success with similar genetic sensor approaches in neuroscience, but this specific method using aquaporins is novel.
Where this research is happening
SANTA BARBARA, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA BARBARA — SANTA BARBARA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUKHERJEE, ARNAB — UNIVERSITY OF CALIFORNIA SANTA BARBARA
- Study coordinator: MUKHERJEE, ARNAB
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.