Developing new probes to measure oxygen levels around cells
Membrane Anchored-Probes for Sensing Analytes at the Cell Surface
This study is testing new tools that can measure oxygen levels around cells to help researchers understand how blood stem cells and leukemia cells act in the bone marrow, which could improve our knowledge of cancer and how it responds to treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10673869 on NIH RePORTER |
What this research studies
This research focuses on creating innovative membrane-anchored probes that can measure oxygen levels in the environment surrounding cells, particularly in the context of cancer biology. By using these probes, researchers aim to gain insights into how hematopoietic stem cells and leukemic cells behave in the bone marrow. The approach involves longitudinal imaging, which allows for tracking changes over time, providing valuable information about disease progression and treatment responses. This could lead to a better understanding of why certain cells thrive in specific areas and how they resist therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing treatment for blood cancers, particularly those with conditions affecting hematopoietic stem cells.
Not a fit: Patients with solid tumors or those not receiving treatment for blood-related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the ability to monitor and improve treatments for cancers involving hematopoietic stem cells.
How similar studies have performed: Other research has shown promise in using similar imaging techniques for monitoring cellular environments, indicating potential success for this novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: El Khatib, Mirna — University of Pennsylvania
- Study coordinator: El Khatib, Mirna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.