Developing new MRI contrast agents using iron coordination cages
Official title: Octahedral iron coordination cages as T1 MRI probes
Funded at State University of New York at Buffalo · NIH-11116076 · Data updated 2026-11-12
This study is looking at new MRI contrast agents made from iron instead of the usual gadolinium, aiming to create safer and better options for people needing MRI scans by improving how well the images show up.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | January 10, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $79,001 |
| NIH project number | 1R03EB037086-01 |
| Project ID | NIH-11116076 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring MRI scans who may benefit from improved contrast agents, particularly those with allergies or sensitivities to gadolinium.
✕Less likely to help
Patients who do not require MRI imaging or who are not affected by gadolinium-based contrast agents may not benefit from this research.
What this research studies
This research focuses on creating innovative MRI contrast agents that utilize iron instead of traditional gadolinium-based agents. The approach involves designing self-assembled iron coordination cages that are stable in water and can enhance MRI imaging by improving the relaxation times of protons. The study will explore various chemical modifications to increase the solubility and effectiveness of these agents, including the addition of amino acids and other functional groups. By characterizing these new compounds through advanced techniques, the research aims to provide safer and more effective options for MRI imaging.
Why it matters
Potential benefit: If successful, this research could lead to safer MRI contrast agents that reduce the risk of adverse reactions associated with gadolinium.
How similar studies have gone: While the use of iron-based agents in MRI is a developing area, there have been promising results in similar research exploring alternative contrast agents.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Morrow, Janet Ruth — State University of New York at Buffalo
- Study coordinator: Morrow, Janet Ruth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.