Developing new mouse models for pediatric acute myeloid leukemia
Official title: Cross-species development and credentialing of pediatric AML models
Funded at Washington University · NIH-10999385 · Data updated 2026-11-12
This study is working to create new mouse models that mimic the different types of high-risk acute myeloid leukemia in children, so researchers can better understand the disease and find more effective treatments for young patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $564,612 |
| NIH project number | 5R01CA285272-02 |
| Project ID | NIH-10999385 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with high-risk acute myeloid leukemia, particularly those with rare molecular subtypes.
✕Less likely to help
Patients with low-risk or non-acute forms of leukemia may not benefit from this research.
What this research studies
This research aims to create and validate new mouse models that accurately represent high-risk pediatric acute myeloid leukemia (AML). By utilizing patient data, the study will focus on the genetic diversity of AML, which includes various molecular subtypes that are often overlooked in current models. The goal is to better understand these subtypes and develop targeted therapies that can improve treatment outcomes for children suffering from this aggressive cancer. The research will involve collaboration among multiple experts to ensure a comprehensive approach to model development.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for children with high-risk pediatric AML.
How similar studies have gone: While there have been advancements in cancer modeling, this approach to developing models specifically for high-risk pediatric AML is relatively novel and has not been extensively tested.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Magee, Jeffrey Alan — Washington University
- Study coordinator: Magee, Jeffrey Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.