Developing new models to study HIV's effects on the brain
Official title: SBIR PHASE 1 (NIH/NIMH TOPIC 002 - DEVELOPMENT OF NOVEL IN-VITRO AND IN-VIVO MODELS TO SUPPORT NEUROHIV RESEARCH)TRITON SYSTEMS INC:1185597 [24-001257]
Funded at Triton Systems, INC. · NIH-11222473 · Data updated 2026-11-12
This study is working on a new way to grow brain cells in the lab to see how HIV affects the brain and nervous system, which could help us understand more about the disease and find better treatments for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Triton Systems, INC. NIH-funded |
| Lab location | 1 site (Chelmsford, United States) |
| Project start | September 23, 2024 |
| Project end | September 22, 2025 |
| Funding year | 2024 |
| Award (this year) | $299,976 |
| NIH project number | 75N95024C00036-0-9999-1 |
| Project ID | NIH-11222473 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may experience neurological symptoms or disorders.
✕Less likely to help
Patients who do not have HIV or related neurological conditions may not benefit from this research.
What this research studies
This research focuses on creating innovative laboratory models to better understand how HIV affects the brain and nervous system. It aims to develop a 3D model that mimics the blood-brain barrier and allows researchers to study how HIV interacts with nerve cells. By establishing co-cultures of brain tissue and neurons, the research will assess important biological markers and the integrity of the blood-brain barrier. This approach could lead to new insights into neuroinflammation and communication between immune cells and neurons.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurological disorders associated with HIV.
How similar studies have gone: Previous research has shown promise in using similar in-vitro models to study neurological diseases, indicating potential for success in this area.
Where this research is happening
-
Triton Systems, INC.
Chelmsford, United States Active
Researchers
- Principal investigator: Bai, Jing — Triton Systems, INC.
- Study coordinator: Bai, Jing
Related research
Other NIH-funded projects on the same topics.
-
A low-cost home test for prostate cancer detection
This study is creating an easy and affordable at-home test that lets you check your PSA levels with just a finger prick, helping you understand your risk for prostate cancer so you can make better health choices.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.