Developing new methods to measure enzyme activity for drug discovery
Official title: Chemically Induced Dimerization Systems for High Throughput Enzyme Assays
Funded at Bellbrook Labs, LLC · NIH-10919964 · Data updated 2026-11-12
This study is working on new ways to measure how well certain enzymes are working, which is important for finding new medicines, especially for conditions related to gene regulation.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bellbrook Labs, LLC NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 20, 2024 |
| Project end | September 19, 2025 |
| Funding year | 2024 |
| Award (this year) | $270,929 |
| NIH project number | 1R43GM154542-01 |
| Project ID | NIH-10919964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from new drug therapies targeting enzyme activity, such as certain cancers or cardiovascular diseases.
✕Less likely to help
Patients who are not affected by diseases related to enzyme dysfunction or who are not seeking new drug therapies may not benefit from this research.
What this research studies
This research focuses on creating innovative systems to detect enzyme activity, which is crucial for developing new drugs. By using chemically induced dimerization (CID) techniques, the team aims to improve the detection of small molecule products generated by enzymes, particularly those involved in epigenetic processes. The approach involves selecting binding domains from native proteins and utilizing them in high throughput screening assays to identify effective drug candidates. This could enhance the efficiency of drug discovery by providing more accurate measurements of enzyme activity.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug discovery processes, ultimately resulting in better treatments for various diseases.
How similar studies have gone: Other research has shown success with similar high throughput screening approaches in drug discovery, indicating a promising avenue for this novel method.
Where this research is happening
-
Bellbrook Labs, LLC
Madison, United States Active
Researchers
- Principal investigator: Lowery, Robert G — Bellbrook Labs, LLC
- Study coordinator: Lowery, Robert G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.