Developing new methods to identify proteins and their modifications at a single-molecule level.
Official title: Chemistry for next-generation single-molecule fluorosequencing technology 2.0.
Funded at Emory University · NIH-10645898 · Data updated 2026-11-12
This study is working on new ways to find tiny amounts of important proteins in the body that can help us understand diseases like cancer better, which could lead to new tests and treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,090,618 |
| NIH project number | 1R01HG012941-01 |
| Project ID | NIH-10645898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancer or other diseases where protein mutations and modifications are significant.
✕Less likely to help
Patients with conditions unrelated to protein mutations or those not requiring advanced diagnostic techniques may not benefit from this research.
What this research studies
This research focuses on advancing techniques to identify proteins and their modifications, known as post-translational modifications (PTMs), at a single-molecule level. By creating new chemical methods, the project aims to improve the detection of low-abundance proteins that play critical roles in diseases like cancer. This could lead to better understanding of biological processes and the discovery of new biomarkers for disease diagnosis and treatment. The approach combines organic chemistry with biological analysis to enhance precision medicine.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in cancer diagnostics and treatment by providing more accurate identification of protein variants and their functions.
How similar studies have gone: Previous research has shown promise in developing single-molecule techniques for protein analysis, indicating potential for success in this novel approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Raj, Monika — Emory University
- Study coordinator: Raj, Monika
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.