Developing new methods to create important organic compounds for medicine
Official title: New Methods for Therapeutic Development
Funded at Vanderbilt University · NIH-11011893 · Data updated 2026-11-12
This study is exploring new ways to create special building blocks for medicines that can help improve drug development, which could lead to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $422,569 |
| NIH project number | 1R35GM156307-01 |
| Project ID | NIH-11011893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that could be treated by new small molecule therapeutics derived from the compounds being developed.
✕Less likely to help
Patients with conditions that do not respond to small molecule therapies may not receive any benefit from this research.
What this research studies
This research focuses on creating innovative reactions and reagents to produce enantioenriched organic compounds, which are essential building blocks for developing small molecule therapeutics. By synthesizing specific types of amines and diamines as single stereoisomers, the project aims to enhance the efficiency of producing complex biologically active natural products. The approach involves using new catalysts and chiral proton complexes to improve the selectivity and effectiveness of these reactions. Patients may benefit from advancements in drug development stemming from these novel synthetic methods.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and targeted therapeutic agents for various medical conditions.
How similar studies have gone: Other research has shown success in developing new synthetic methods for small molecule therapeutics, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Johnston, Jeffrey Nicholas — Vanderbilt University
- Study coordinator: Johnston, Jeffrey Nicholas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.