Developing new methods to create drugs that can target difficult proteins.
Official title: Pharmacokinetics-Based DNA-Encoded Library Screening
Funded at San Diego State University · NIH-11229276 · Data updated 2026-11-12
This study is exploring new ways to create drugs that can better target tough-to-reach proteins in the body, which could lead to more effective treatments for diseases like viral infections, helping patients find relief from their conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | April 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $248,988 |
| NIH project number | 4R00GM149941-03 |
| Project ID | NIH-11229276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with conditions related to viral infections or diseases involving challenging protein interactions.
✕Less likely to help
Patients with conditions that do not involve protein-protein interactions or those who are not affected by viral infections may not benefit from this research.
What this research studies
This research focuses on creating innovative technologies to design new types of drugs, specifically cyclic peptides, which can target proteins that are typically hard to reach with conventional medications. By using a high-throughput screening method, the researchers aim to identify which cyclic peptides can effectively penetrate cell membranes. This approach could lead to the discovery of new treatments for diseases caused by challenging protein interactions, such as those seen in viral infections. Patients may benefit from more effective therapies that target previously undruggable proteins.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs that effectively treat diseases caused by difficult-to-target proteins.
How similar studies have gone: Other research has shown promise in using similar high-throughput screening methods to identify effective drug candidates, suggesting that this approach could yield valuable results.
Where this research is happening
-
San Diego State University
San Diego, United States Active
Researchers
- Principal investigator: Hu, Juan — San Diego State University
- Study coordinator: Hu, Juan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.