Developing new methods to create complex natural compounds and discover potential cancer treatments.
Official title: Synthesis of Natural Products by Oxidative Dearomatization and Discovery of BRAT1 Degraders
Funded at University of Central Florida · NIH-10874296 · Data updated 2026-11-12
This study is looking at new ways to create natural compounds that could lead to better treatments for patients, focusing on specific substances that might help improve health by interacting with proteins in the body.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Central Florida NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $441,469 |
| NIH project number | 1R15GM154274-01 |
| Project ID | NIH-10874296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that could be treated by the novel compounds developed through this research.
✕Less likely to help
Patients with conditions unrelated to the targeted proteins or those who do not respond to the types of therapies being developed may not receive benefit from this research.
What this research studies
This research focuses on creating new synthetic methods to produce complex natural compounds, specifically targeting the synthesis of Lycopodium alkaloids and BRAT1 degraders. By using oxidative conditions to modify phenolic compounds, the team aims to explore how these changes can affect the biological activity of these natural products. The research will also investigate the interactions between specific compounds and proteins to design effective therapeutic agents. Patients may benefit from the potential new treatments that arise from these discoveries.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for conditions related to the targeted proteins, potentially improving treatment options for patients.
How similar studies have gone: Other research has shown promise in developing synthetic methods for natural products and targeting specific proteins, indicating that this approach could yield significant advancements.
Where this research is happening
-
University of Central Florida
Orlando, United States Active
Researchers
- Principal investigator: Yuan, Yu — University of Central Florida
- Study coordinator: Yuan, Yu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.