Developing new methods to create complex molecules for drug discovery
Official title: Controlled Catalytic Functionalization of Alkenes and Alkynes
Funded at Scripps Research Institute, the · NIH-11012200 · Data updated 2026-11-12
This study is working on new ways to create important small molecules that help scientists discover new medicines, using special tools to make the process easier and more efficient, which could lead to better treatments for various health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $524,400 |
| NIH project number | 1R35GM156483-01 |
| Project ID | NIH-11012200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions that currently lack effective treatments due to challenges in drug development.
✕Less likely to help
Patients with well-established treatments for their conditions may not see direct benefits from this research.
What this research studies
This research focuses on improving the process of drug discovery by creating new methods to synthesize complex small molecules that are essential for evaluating potential new medications. The approach involves using advanced transition metal catalysts to facilitate chemical reactions that allow for the efficient construction of intricate compounds from simpler starting materials. By achieving precise control over the chemical structure of these molecules, the research aims to enhance the toolkit available for drug development, ultimately benefiting a wide range of medical conditions.
Why it matters
Potential benefit: If successful, this research could significantly accelerate the development of new drugs by making it easier to create complex molecules needed for testing.
How similar studies have gone: Other research has shown success in using advanced synthetic methods to improve drug discovery, indicating that this approach has the potential for significant impact.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Engle, Keary Mark — Scripps Research Institute, the
- Study coordinator: Engle, Keary Mark
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.