Developing new methods to create chemical probes for unexplored biological targets
Official title: Expanding the chemical probe development paradigm toward underexplored targets
Funded at Albert Einstein College of Medicine · NIH-10940110 · Data updated 2026-11-12
This study is working on creating new tools to help find better medicines by focusing on proteins that haven't been studied much before, which could lead to exciting new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $420,000 |
| NIH project number | 1R35GM155249-01 |
| Project ID | NIH-10940110 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that are linked to underexplored biological targets, particularly those that lack effective treatments.
✕Less likely to help
Patients with well-characterized diseases that already have established treatments may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing the development of chemical probes that can target previously underexplored proteins, which are crucial for drug discovery. By utilizing a novel high-throughput medicinal chemistry platform, the project aims to streamline the process of optimizing initial drug candidates to improve their effectiveness and selectivity. The approach combines advanced chemical techniques with a focus on proteins that lack distinct binding sites, potentially leading to breakthroughs in treating various diseases. Patients may benefit from new therapies that arise from these innovative drug discovery methods.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective medications for diseases that currently have limited treatment options.
How similar studies have gone: While the approach of targeting underexplored proteins is innovative, similar methodologies in drug discovery have shown promise in other contexts, suggesting potential for success.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Kitamura, Seiya — Albert Einstein College of Medicine
- Study coordinator: Kitamura, Seiya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.