Developing new methods to create aptamers for difficult targets in clinical chemistry
Analog-based Approaches to Isolation of Aptamers for Challenging Targets
This study is all about creating better tools to help doctors detect small substances in your body, like drugs or other important markers, so they can make more accurate decisions about your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10647742 on NIH RePORTER |
What this research studies
This research focuses on improving the development of aptamers, which are specialized receptors used for the precise detection of small molecules in clinical settings. The team at Columbia University is working on isolating high-quality aptamers for various substances, including drugs and metabolites, to enhance diagnostic tests for both home and clinical laboratory use. They are exploring innovative selection methods to overcome challenges faced in isolating aptamers for particularly difficult targets. By validating these aptamers with actual patient samples, the research aims to contribute to better clinical decision-making.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who require precise monitoring of specific small molecules, such as those with metabolic disorders or substance use disorders.
Not a fit: Patients who do not have conditions requiring the detection of small molecules or those not involved in the targeted substances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and rapid diagnostic tests for various medical conditions.
How similar studies have performed: Previous research has shown success in developing aptamers for various targets, but this approach aims to tackle particularly challenging targets that have not been effectively addressed before.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Stojanovic, Milan N — Columbia University Health Sciences
- Study coordinator: Stojanovic, Milan N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.