Developing new methods to create antimicrobial peptides for treating infections
Chemical methods to prepare bioactive cyclic and lassoed peptide therapeutics
['FUNDING_OTHER'] · UNIVERSITY OF UTAH · NIH-11110403
This study is exploring new ways to create special proteins that could help fight tough infections caused by bacteria that don't respond to many medicines, aiming to offer better treatment options for patients dealing with these challenging infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11110403 on ClinicalTrials.gov |
What this research studies
This research focuses on creating innovative chemical methods to synthesize bioactive cyclic and lassoed peptides that can serve as potential antimicrobial therapies. By utilizing advanced techniques, the team aims to design peptides that are effective against multidrug-resistant Gram-negative bacteria, which are a significant challenge in modern medicine. The project combines experimental approaches with computational modeling to optimize the stability and effectiveness of these peptides. Patients may benefit from new treatment options that could combat resistant infections more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by multidrug-resistant Gram-negative bacteria.
Not a fit: Patients with infections caused by non-resistant bacteria or those who do not respond to peptide-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antimicrobial therapies that effectively treat infections caused by resistant bacteria.
How similar studies have performed: Other research has shown promise in developing peptide-based therapies for infections, indicating that this approach has potential for success.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROBERTS, ANDREW GEORGE — UNIVERSITY OF UTAH
- Study coordinator: ROBERTS, ANDREW GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.