Developing new methods to create antimicrobial peptides for treating infections
Official title: Chemical methods to prepare bioactive cyclic and lassoed peptide therapeutics
Funded at University of Utah · NIH-11110403 · Data updated 2026-11-12
This study is exploring new ways to create special proteins that could help fight tough infections caused by bacteria that don't respond to many medicines, aiming to offer better treatment options for patients dealing with these challenging infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | June 14, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 5R35GM155457-02 |
| Project ID | NIH-11110403 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by multidrug-resistant Gram-negative bacteria.
✕Less likely to help
Patients with infections caused by non-resistant bacteria or those who do not respond to peptide-based therapies may not benefit from this research.
What this research studies
This research focuses on creating innovative chemical methods to synthesize bioactive cyclic and lassoed peptides that can serve as potential antimicrobial therapies. By utilizing advanced techniques, the team aims to design peptides that are effective against multidrug-resistant Gram-negative bacteria, which are a significant challenge in modern medicine. The project combines experimental approaches with computational modeling to optimize the stability and effectiveness of these peptides. Patients may benefit from new treatment options that could combat resistant infections more effectively.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antimicrobial therapies that effectively treat infections caused by resistant bacteria.
How similar studies have gone: Other research has shown promise in developing peptide-based therapies for infections, indicating that this approach has potential for success.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Roberts, Andrew George — University of Utah
- Study coordinator: Roberts, Andrew George
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.