Developing new methods to control protein phosphorylation in cells
Engineered orthogonal signaling systems for selective phosphorylation of protein kinase substrates
['FUNDING_R21'] · YALE UNIVERSITY · NIH-10952454
This study is exploring a new way to help scientists understand how certain proteins in our cells communicate by using special technology to add a chemical tag to them, which could eventually lead to better treatments for diseases.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10952454 on ClinicalTrials.gov |
What this research studies
This research focuses on creating innovative technology to selectively phosphorylate specific protein substrates involved in cell signaling. By engineering a mutant version of a kinase, the team aims to direct phosphorylation to a chosen substrate, allowing for a better understanding of how these modifications affect cellular functions. The study will utilize the tumor suppressor kinase LKB1 as a model to demonstrate the feasibility of this approach, which could lead to advancements in targeted therapies for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to dysregulated protein kinase activity, such as certain cancers.
Not a fit: Patients with conditions unrelated to protein kinase signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise treatments for diseases by enhancing our understanding of protein signaling pathways.
How similar studies have performed: Other research has shown promise in using engineered kinases for targeted phosphorylation, indicating that this approach has potential for success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TURK, BENJAMIN E — YALE UNIVERSITY
- Study coordinator: TURK, BENJAMIN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer cell line, Cancers