Developing new methods to control protein phosphorylation in cells
Official title: Engineered orthogonal signaling systems for selective phosphorylation of protein kinase substrates
Funded at Yale University · NIH-10952454 · Data updated 2026-11-12
This study is exploring a new way to help scientists understand how certain proteins in our cells communicate by using special technology to add a chemical tag to them, which could eventually lead to better treatments for diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 6, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $391,531 |
| NIH project number | 1R21CA293623-01 |
| Project ID | NIH-10952454 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to dysregulated protein kinase activity, such as certain cancers.
✕Less likely to help
Patients with conditions unrelated to protein kinase signaling may not benefit from this research.
What this research studies
This research focuses on creating innovative technology to selectively phosphorylate specific protein substrates involved in cell signaling. By engineering a mutant version of a kinase, the team aims to direct phosphorylation to a chosen substrate, allowing for a better understanding of how these modifications affect cellular functions. The study will utilize the tumor suppressor kinase LKB1 as a model to demonstrate the feasibility of this approach, which could lead to advancements in targeted therapies for various diseases.
Why it matters
Potential benefit: If successful, this research could lead to more precise treatments for diseases by enhancing our understanding of protein signaling pathways.
How similar studies have gone: Other research has shown promise in using engineered kinases for targeted phosphorylation, indicating that this approach has potential for success.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Turk, Benjamin E — Yale University
- Study coordinator: Turk, Benjamin E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.