Developing new methods for creating pharmaceutical ingredients using hydrogen
Official title: Catalytic C-C Coupling via Hydrogen Transfer
Funded at University of Texas at Austin · NIH-10995971 · Data updated 2026-11-12
This study is exploring new ways to make important ingredients for medicines more efficiently and cleanly, which could lead to better treatments for patients, including those with cancer or infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $425,960 |
| NIH project number | 1R35GM155947-01 |
| Project ID | NIH-10995971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals requiring new or improved medications for cancer or bacterial infections.
✕Less likely to help
Patients who are not affected by cancer or bacterial infections may not receive direct benefits from this research.
What this research studies
This research focuses on creating innovative catalytic methods for forming carbon-carbon bonds, which are essential in the production of pharmaceutical ingredients. By utilizing hydrogen and other compounds, the team aims to develop cleaner and more efficient processes for synthesizing higher alcohols and amines from lower ones. This work not only enhances the efficiency of chemical reactions but also supports the synthesis of natural products that may have anti-cancer or anti-bacterial properties. Patients may benefit from improved pharmaceutical products resulting from these advanced methods.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and safer pharmaceutical agents for treating various conditions.
How similar studies have gone: Previous research in catalytic methods for pharmaceutical synthesis has shown promising results, indicating that this approach could lead to significant advancements.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Krische, Michael J — University of Texas at Austin
- Study coordinator: Krische, Michael J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.