Developing new methods for creating complex drug-like molecules
Exploiting Unconventional Building Blocks in Chemical Synthesis
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11057094
This study is all about finding new and better ways to create complex molecules that could lead to new medicines, using some unique building blocks and techniques to make them more like the natural compounds we find in existing drugs.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11057094 on ClinicalTrials.gov |
What this research studies
This research focuses on creating innovative methods to synthesize complex molecules that can lead to new drug treatments. By utilizing unconventional building blocks, such as amides and strained cyclic alkynes, the project aims to develop reliable and efficient methodologies for constructing intricate chemical structures. These methods will help in producing stereochemically rich scaffolds that resemble naturally occurring small molecules and medicines. The research employs nickel catalysis and chemoenzymatic techniques to explore new ways of building these important molecular linkages.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions that could be treated by new pharmacological therapies derived from complex small molecules.
Not a fit: Patients who are not seeking new drug treatments or those with conditions that do not respond to pharmacological interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel drug treatments that are more effective and have fewer side effects.
How similar studies have performed: Other research has shown success in developing new synthetic methodologies for drug discovery, indicating that this approach has potential for significant advancements.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARG, NEIL K — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: GARG, NEIL K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.