Developing new materials to help nerves heal after injury
Ionically Conductive Polymeric Biomaterials and Grafts for Nerve Regeneration
This study is exploring new ways to help people with serious nerve injuries heal better after surgery by using special materials that can deliver helpful treatments, which could lead to improved recovery and nerve function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11004162 on NIH RePORTER |
What this research studies
This research focuses on improving the healing process for patients with peripheral nerve injuries (PNI) that require surgical repair, particularly when there are large gaps in the nerve. The team is working on creating innovative grafts that combine electrical and chemical stimulation to enhance nerve regeneration. By using a biodegradable scaffold that can deliver a drug called 4-aminopyridine, the research aims to improve the effectiveness of nerve repair and recovery. Patients may benefit from these advanced materials that could lead to better outcomes in nerve function and healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant peripheral nerve injuries requiring surgical intervention.
Not a fit: Patients with minor nerve injuries that do not require surgical repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve recovery and function for patients with severe nerve injuries.
How similar studies have performed: Previous research has shown promise in using electrical and chemical stimulation for nerve repair, indicating potential success for this novel approach.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Kumbar, Sangamesh Gurappa — University of Connecticut Sch of Med/dnt
- Study coordinator: Kumbar, Sangamesh Gurappa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.