Developing new materials for delivering gene therapies to treat diabetic skin wounds
Official title: Modular Toolbox of Protein and Lipid Hybrid Biomaterials for siRNA Delivery
Funded at New York University · NIH-11141906 · Data updated 2026-11-12
This study is exploring a new way to help heal stubborn diabetic skin wounds by using special materials that can deliver gene therapies directly to the problem area, making it easier for patients to get better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $527,241 |
| NIH project number | 5R01EB035146-02 |
| Project ID | NIH-11141906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic diabetic skin wounds who have not responded well to conventional treatments.
✕Less likely to help
Patients with acute wounds or those not suffering from diabetes may not receive benefits from this research.
What this research studies
This research focuses on creating innovative biomaterials that can effectively deliver gene therapies, specifically short interfering RNA (siRNA), to treat chronic diabetic skin wounds. The approach involves designing a hybrid nanovehicle, called lipoproteoplex (LPP), which combines proteins and lipids to enhance the delivery and efficacy of the therapeutic agents. By improving how these materials enter cells and release their cargo, the research aims to overcome current limitations in gene delivery technologies. Patients with chronic wounds may benefit from this advanced treatment option that targets the underlying issues more effectively.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment for chronic diabetic skin wounds, potentially reducing healing times and improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using biomaterials for gene delivery, indicating that this approach could lead to significant advancements in treatment options.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Montclare, Jin Kim — New York University
- Study coordinator: Montclare, Jin Kim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.