Developing new immunotherapies for childhood cancers
Official title: Next Generation Immunotherapies for Pediatric Cancers
Funded at Stanford University · NIH-10981647 · Data updated 2026-11-12
This study is working on new and safer ways to help kids with cancer by using special treatments that boost their immune system, aiming to make them more effective and have fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2031 |
| Funding year | 2024 |
| Award (this year) | $931,841 |
| NIH project number | 1R35CA283888-01A1 |
| Project ID | NIH-10981647 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with aggressive or treatment-resistant cancers.
✕Less likely to help
Patients with non-cancerous conditions or those outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research focuses on creating advanced immunotherapies specifically designed for treating pediatric cancers. It aims to improve the effectiveness and safety of cancer treatments for children by utilizing innovative approaches such as CAR T cells and CRISPR technology. The project will investigate the biology of childhood cancers and how the immune system can be harnessed to target these diseases more effectively. By understanding the mechanisms of immune evasion, the research seeks to develop therapies that not only improve cure rates but also reduce harmful side effects associated with traditional treatments.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective cancer treatments for children, improving their chances of survival and quality of life.
How similar studies have gone: Previous research has shown promising results with immunotherapy approaches in pediatric oncology, indicating potential for success in this novel application.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Mackall, Crystal — Stanford University
- Study coordinator: Mackall, Crystal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.