Developing new imaging tools to study zinc levels in cells
Probes and techniques for biological imaging applications - Revision - 3
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10581074
This study is all about developing special tools to see how zinc levels change in cells, especially in those that help control blood sugar, which could help us understand more about type 2 diabetes and how it affects the body.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10581074 on ClinicalTrials.gov |
What this research studies
This research focuses on creating advanced imaging probes and techniques to measure zinc ion levels in various parts of cells, particularly in pancreatic islet cells. By developing fluorescent sensors that can specifically target different cellular compartments, the research aims to enhance our understanding of zinc's role in biological processes and its implications in diseases like type 2 diabetes. The project combines these sensors with flow cytometry to analyze zinc dynamics in living cells, which could lead to new insights into cellular function and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes or those at risk of developing this condition.
Not a fit: Patients who do not have type 2 diabetes or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapeutic strategies for managing type 2 diabetes and related conditions.
How similar studies have performed: Previous research has shown promise in using imaging probes for studying metal ion dynamics in cells, indicating that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, WEN-HONG — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: LI, WEN-HONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Diabetes Mellitus, diabetes, Non-Insulin-Dependent Diabetes Mellitus, Adult-Onset Diabetes Mellitus, Ketosis-Resistant Diabetes Mellitus