Developing new imaging tools to study zinc levels in cells
Probes and techniques for biological imaging applications
This study is all about developing special tools to see how much zinc is in different parts of cells, especially in those that help control insulin, to better understand how zinc affects our health and could help with diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10448466 on NIH RePORTER |
What this research studies
This research focuses on creating advanced fluorescent sensors to measure zinc ion levels in various parts of cells, particularly in secretory granules and the cytosol. By engineering these sensors, the project aims to enhance our understanding of zinc's role in biological processes and its implications in diseases. The approach involves using cell-based assays and flow cytometry to analyze zinc dynamics in pancreatic islet cells, which are crucial for insulin regulation. This work could lead to significant advancements in biomedical research and potential therapeutic applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes or related metabolic disorders, particularly those interested in the biochemical aspects of their condition.
Not a fit: Patients who do not have diabetes or related metabolic disorders may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could improve our understanding of zinc's role in diabetes and other diseases, potentially leading to new diagnostic or therapeutic strategies.
How similar studies have performed: Previous research has shown promise in using fluorescent sensors for studying metal ion dynamics, indicating that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Li, Wen-Hong — Ut Southwestern Medical Center
- Study coordinator: Li, Wen-Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.