Developing new imaging techniques for Alzheimer's disease
Optical probe and instrumentation development for in vivo near-infrared fluorescence imaging of Alzheimer's disease
This study is working on new tools to help scientists see important signs of Alzheimer's disease in living mice, which could lead to better ways to understand and treat the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11019810 on NIH RePORTER |
What this research studies
This research focuses on creating advanced optical probes and imaging instruments to visualize the key features of Alzheimer's disease in living mice. By utilizing near-infrared fluorescence imaging, the study aims to provide a non-invasive method to observe the accumulation of amyloid plaques and neurofibrillary tangles, which are critical indicators of the disease. The approach seeks to improve the resolution of imaging techniques, allowing for better understanding of disease progression and the effectiveness of potential treatments. This innovative method could lead to significant advancements in how Alzheimer's disease is studied and treated.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those with early symptoms of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those who do not exhibit amyloid plaque accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and early detection of Alzheimer's disease, improving treatment options for patients.
How similar studies have performed: Previous research has shown promise with optical imaging techniques, but this specific approach using NIR-II fluorescence is relatively novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hou, Steven S. — Massachusetts General Hospital
- Study coordinator: Hou, Steven S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.