Developing new imaging probes for better physiological chemistry sensing
Official title: New Classes of Electron Paramagnetic Resonance Imaging Probes With High-Spin Metal Complexes
Funded at Ohio State University · NIH-10911225 · Data updated 2026-11-12
This study is working on new metal-based tools that can help doctors take safer and clearer images of the body, combining advanced techniques to better understand how our bodies work without using harmful methods.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $385,345 |
| NIH project number | 5R35GM150894-03 |
| Project ID | NIH-10911225 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring detailed imaging of physiological chemistry, such as those with complex medical conditions that are difficult to diagnose.
✕Less likely to help
Patients who do not require advanced imaging techniques or those with conditions that can be adequately diagnosed with existing methods may not benefit from this research.
What this research studies
This research focuses on creating innovative metal complexes that can be used as noninvasive probes for electron paramagnetic resonance imaging (EPRI). By overcoming the limitations of current imaging techniques, the goal is to integrate EPRI with conventional MRI to produce detailed chemical and anatomical maps of the body. The study will explore high-spin metal complexes that allow for safer imaging without the need for dangerous high-energy microwaves. This approach aims to enhance the capabilities of EPRI, making it a more effective tool for understanding physiological chemistry.
Why it matters
Potential benefit: If successful, this research could lead to advanced imaging techniques that provide more accurate and comprehensive insights into physiological conditions.
How similar studies have gone: While the integration of EPRI with MRI is a novel approach, previous research has shown promise in using metal complexes for imaging, suggesting potential for success in this area.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Zadrozny, Joseph M — Ohio State University
- Study coordinator: Zadrozny, Joseph M
Related research
Other NIH-funded projects on the same topics.
-
Understanding how trinucleotide repeat expansions cause disease
A research project at Ohio State University is exploring how tiny DNA repeats become unstable and drive neurological and muscular diseases, with potential implications for future therapies.
-
Pediatric Prehospital Airway Resuscitation for Critically Ill Children
This grant tests the best way for paramedics to manage breathing tubes and other airways in seriously ill children before they reach the hospital.
-
From Social Breakups to Brain Changes in Alzheimer’s and Related Dementias
This grant explores how losing social connections may trigger brain changes and inflammation linked to Alzheimer’s disease and related dementias.
-
Understanding why patients with blood cancers start and stick with oral cancer medicines
A study to learn what helps or hinders Black patients with blood cancers in starting and continuing their prescribed oral cancer medicines.
-
How sex and hormones affect alcohol's impact on sleep in adults
This study tests how sex and hormone changes influence how alcohol disrupts sleep in healthy adults, with a focus on women aged 21-45.
-
Natural products to block IL-8 signaling and prevent Barrett's Esophagus from turning into esophageal cancer
A搜索-friendly plan to use safe natural compounds to interrupt a key inflammatory signal (IL-8) and stop Barrett’s esophagus from turning into esophageal cancer in people with GERD.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.