Developing new drugs to treat obesity by targeting specific enzymes.
Official title: Discovery and optimization of novel, selective HDAC11 inhibitors for the treatment of obesity and related diseases.
Funded at Myracle Therapeutics INC · NIH-10921027 · Data updated 2026-11-12
This study is looking at new ways to help people with obesity by targeting a specific enzyme called HDAC11, which affects how our body uses fat, with the hope of improving metabolism and overall health.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Myracle Therapeutics INC NIH-funded |
| Lab location | 1 site (East Hanover, United States) |
| Project start | July 25, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $324,466 |
| NIH project number | 1R44DK139886-01 |
| Project ID | NIH-10921027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals struggling with obesity or related metabolic disorders.
✕Less likely to help
Patients who are not affected by obesity or metabolic diseases may not receive any benefit from this research.
What this research studies
This research focuses on creating selective inhibitors for the enzyme HDAC11, which may help improve metabolic health and treat obesity. By understanding how HDAC11 affects fat tissue, the researchers aim to enhance energy expenditure and reduce fat dysfunction. The approach involves studying the effects of these inhibitors on brown and white adipose tissues, which play crucial roles in metabolism. Patients may benefit from new therapeutic options that target the underlying mechanisms of obesity and related metabolic diseases.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for obesity and improve metabolic health in patients.
How similar studies have gone: Other research has shown promise in targeting metabolic pathways for obesity treatment, indicating potential success for this approach.
Where this research is happening
-
Myracle Therapeutics INC
East Hanover, United States Active
Researchers
- Principal investigator: Bell, Dawn — Myracle Therapeutics INC
- Study coordinator: Bell, Dawn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.