Developing new combination therapies for aggressive nerve sheath tumors in children
Preclinical-Clinical Trials Collaboration to effectively advance new combination therapies for malignant peripheral nerve sheath tumors
This study is working to find better treatments for children with a tough type of tumor called malignant peripheral nerve sheath tumors, which can happen with neurofibromatosis type 1, by combining new ideas from lab research and real-life patient experiences.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10909160 on NIH RePORTER |
What this research studies
This research focuses on malignant peripheral nerve sheath tumors (MPNST), a severe complication of neurofibromatosis type 1 (NF1) that primarily affects children. The project aims to create a pipeline that connects laboratory discoveries with clinical applications, allowing for the rapid development and testing of new combination therapies. By utilizing insights from both preclinical models and clinical trials, the research seeks to identify effective treatment options for patients with inoperable tumors. The collaboration involves experts from various institutions to ensure a comprehensive approach to tackling this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1.
Not a fit: Patients with other types of tumors or those not diagnosed with neurofibromatosis type 1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for children suffering from malignant peripheral nerve sheath tumors.
How similar studies have performed: Previous research has shown promise in developing combination therapies for similar aggressive cancers, indicating potential for success in this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cichowski, Karen M — Brigham and Women's Hospital
- Study coordinator: Cichowski, Karen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.