Developing new chemical tools to understand gene regulation
Chemical Probe Development for Epigenetic Complexes Enabled by Protein-Observed 19F NMR
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-11009919
This study is looking at how certain proteins help control gene activity, with the goal of finding new treatments for patients by better understanding these processes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11009919 on ClinicalTrials.gov |
What this research studies
This research focuses on creating innovative chemical probes to explore how epigenetic complexes regulate gene expression. By utilizing advanced techniques like 19F NMR, the team aims to identify specific protein interactions and understand the dynamics of these interactions at a molecular level. This work could lead to the development of new therapies targeting epigenetic mechanisms, particularly through the study of bromodomain-containing proteins. Patients may benefit from new treatments that arise from a better understanding of these complex biological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with cancers or disorders influenced by epigenetic mechanisms.
Not a fit: Patients with conditions unrelated to epigenetic regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for various cancers and other diseases linked to epigenetic changes.
How similar studies have performed: Other research has shown promise in using chemical probes for studying epigenetic mechanisms, indicating that this approach could be effective.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POMERANTZ, WILLIAM CHARLES KRAUSE — UNIVERSITY OF MINNESOTA
- Study coordinator: POMERANTZ, WILLIAM CHARLES KRAUSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer progression, Cancers