Developing new cell-based therapies to treat inflammatory diseases
Official title: Bioengineering of Enucleated Cell Therapeutics for Treating Inflammatory Diseases
Funded at University of California, San Diego · NIH-11098903 · Data updated 2026-11-12
This study is exploring a new way to help people with inflammatory diseases by using specially modified stem cells that can find and deliver treatments right where they are needed most, making the healing process safer and more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $481,438 |
| NIH project number | 1R01EB036986-01 |
| Project ID | NIH-11098903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory diseases, such as chronic pancreatitis.
✕Less likely to help
Patients with acute inflammatory conditions or those not responding to conventional therapies may not benefit from this research.
What this research studies
This research focuses on creating innovative cell-based therapeutics that can precisely deliver treatments to inflamed and damaged tissues in patients with inflammatory diseases. The approach involves using genetically engineered mesenchymal stem cells, which are modified to enhance their ability to target specific areas of inflammation. These modified cells, called Cargocytes, are designed to respond to signals from diseased tissues, allowing for more effective and safer delivery of therapeutic agents. By improving drug delivery mechanisms, this research aims to enhance treatment outcomes for patients suffering from chronic inflammatory conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients with inflammatory diseases, reducing side effects and improving recovery.
How similar studies have gone: Previous research has shown promise in using engineered cell therapies for targeted drug delivery, indicating potential success for this novel approach.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Klemke, Richard L. — University of California, San Diego
- Study coordinator: Klemke, Richard L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.