Developing new catalysts for chemical reactions involving carbonyls and olefins
Official title: Mechanism-Based Design of Iron-Mediated Carbonyl-Olefin Metathesis Protocols
Funded at Loyola University of Chicago · NIH-10203100 · Data updated 2026-11-12
This study is looking at ways to make chemical reactions better for creating important medicines by using special iron-based helpers, called catalysts, to improve how these reactions work, making them faster and more efficient while being kinder to the environment.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | May 1, 2018 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $403,593 |
| NIH project number | 2R15GM128126-02 |
| Project ID | NIH-10203100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who may benefit from this research are those requiring medications that rely on the synthesis of carbonyl and olefin compounds.
✕Less likely to help
Patients who do not require medications produced through carbonyl-olefin metathesis may not see any direct benefits from this research.
What this research studies
This research focuses on improving chemical reactions that involve carbonyl and olefin compounds, which are important in the production of pharmaceuticals. By studying how iron-based catalysts work, the researchers aim to design new catalysts that can enhance reaction efficiency and selectivity. They will use various techniques, including synthetic methods and computational modeling, to understand how different ligands affect the catalytic process. This work could lead to more effective and environmentally friendly chemical synthesis methods.
Why it matters
Potential benefit: If successful, this research could lead to more efficient production of pharmaceuticals, potentially lowering costs and improving drug availability.
How similar studies have gone: While the specific approach of using iron catalysts in this context is innovative, similar research in catalyst design has shown promise in improving chemical synthesis outcomes.
Where this research is happening
-
Loyola University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Devery, James John — Loyola University of Chicago
- Study coordinator: Devery, James John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.