Developing new cancer treatments by targeting a specific protein activation
Targeting the Sam68-stimulated PARP1 activation for cancer treatment
This study is looking for better ways to treat cancer by finding new medicines that can specifically target a protein called PARP1, which helps cancer cells repair their DNA, while causing fewer side effects for healthy cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11085177 on NIH RePORTER |
What this research studies
This research focuses on improving cancer treatment by targeting the activation of a protein called PARP1, which is crucial for DNA repair in cancer cells. The current treatments using PARP1 inhibitors can affect normal cells, leading to unwanted side effects. The researchers aim to identify new inhibitors that specifically target PARP1 activation stimulated by another protein, Sam68, using high throughput screening methods. This approach could lead to more effective and safer cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that are currently treated with PARP1 inhibitors.
Not a fit: Patients with cancers that do not involve PARP1 activation or those who are not receiving PARP1 inhibitor treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments with fewer side effects for patients.
How similar studies have performed: Other research has shown promise in targeting specific protein activations for cancer treatment, but this approach is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wan, Fengyi — Johns Hopkins University
- Study coordinator: Wan, Fengyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.