Developing new biomaterials to treat heart failure with preserved ejection fraction
Non-racemic metabolic biomaterials for HFpEF
This study is looking for new ways to help people with heart failure that keeps their heart pumping well, by creating special materials that can help the immune system work better and reduce heart damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10896329 on NIH RePORTER |
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition affecting about half of all heart failure patients. The study aims to create innovative biomaterial-based immunomodulators that target specific immune cells involved in HFpEF. By synthesizing and testing these materials in laboratory and animal models, the researchers hope to find effective treatments that can delay the onset of HFpEF and reduce associated cardiac fibrosis. The approach involves a series of experiments to optimize these biomaterials for safety and efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction.
Not a fit: Patients with other types of heart failure or those without a diagnosis of HFpEF may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from HFpEF, potentially improving their quality of life and health outcomes.
How similar studies have performed: While this approach is innovative, similar strategies targeting immune modulation in heart failure have shown promise in preliminary studies.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Maiseyeu, Andrei — Case Western Reserve University
- Study coordinator: Maiseyeu, Andrei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.