Developing new antiviral drugs to fight poxvirus infections
Advancement of poxvirus inhibitor
This study is working on new medicines to help fight poxvirus infections like smallpox and Monkeypox, especially for people who might be at risk as immunity decreases, by creating compounds that can stop the virus from making copies of itself.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10808174 on NIH RePORTER |
What this research studies
This research focuses on creating small molecule therapeutics to combat poxvirus infections, including smallpox, Monkeypox, and Cowpox. As immunity to these viruses decreases globally, the need for effective antiviral treatments has become critical. The team is investigating a new class of compounds that show promise in inhibiting poxviruses by targeting their RNA polymerase, which is essential for viral replication. The research involves medicinal chemistry techniques to enhance the potency and safety of these compounds, aiming to develop effective treatments for patients at risk of poxviral diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk of poxvirus infections, such as healthcare workers or those in endemic regions.
Not a fit: Patients who are not at risk for poxvirus infections or those who have already been vaccinated against these viruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral medications that protect against serious poxvirus infections.
How similar studies have performed: Previous research has shown promise in developing antiviral agents for poxviruses, but this approach using non-nucleoside small molecules is relatively novel.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Connor, John H — Boston University Medical Campus
- Study coordinator: Connor, John H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.