Developing new antioxidants to combat oxidative stress in diseases.
Official title: Building Better Antioxidants: Virtual Screening, Synthesis, and Characterization of Multifunctional Small Molecules Combining Nrf2 Pathway Activation and Direct Antioxidant Activity
Funded at Texas Christian University · NIH-10360130 · Data updated 2026-11-12
This study is working on developing new tiny molecules that can help protect your cells from damage caused by oxidative stress, which is linked to conditions like neurodegenerative diseases and cataracts, with the hope of finding better treatments for people dealing with these issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Christian University NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project start | June 1, 2018 |
| Project end | January 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $379,063 |
| NIH project number | 2R15GM123463-02 |
| Project ID | NIH-10360130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neurodegenerative diseases or ocular conditions that are exacerbated by oxidative stress.
✕Less likely to help
Patients with conditions unrelated to oxidative stress or those who do not have neurodegenerative or ocular diseases may not benefit from this research.
What this research studies
This research focuses on creating small molecules that can effectively reduce oxidative stress, which is linked to neurodegenerative and eye diseases. The approach involves using virtual screening and rational design to identify and synthesize these molecules, which will be tested in cellular models of diseases like cataracts. The goal is to enhance the molecules' ability to scavenge free radicals and activate the Nrf2 pathway, which helps protect cells from damage. By understanding how these new compounds work, the research aims to provide better therapeutic options for patients suffering from these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve outcomes for patients with neurodegenerative and ocular diseases.
How similar studies have gone: Previous research has shown promise in developing antioxidants that target oxidative stress, indicating that this approach has potential for success.
Where this research is happening
-
Texas Christian University
Fort Worth, United States Active
Researchers
- Principal investigator: Green, Kayla N — Texas Christian University
- Study coordinator: Green, Kayla N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.